BDBM5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870
SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
InChI Key InChIKey=AAKJLRGGTJKAMG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 5446
Affinity DataKd: 3.10nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 40nMAssay Description:Average Binding Constant for GAK; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to human GAK fused to T7 bacteriophage after 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding constant for GAK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to DNA-tagged human GAK expressed in Escherichia coli BL21 using immobilised ligand incubated for 1 hr by quantitative PCRMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
Affinity DataIC50: 910nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to T7-tagged GAK (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding affinity to GAK (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding affinity to GAK (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair